City defeated Borussia Monchengladbach in their first group game in the Champions League this season, before drawing away at Celtic.
Barcelona have won both of their opening games against the same opposition, firing seven goals past Celtic in a record victory.
Team News
Sergio Aguero is expected to return to the starting line-up, having come off the bench against Everton at the weekend. Claudio Bravo and Nolito are expected to start against their former side, whilst Vincent Kompany could also start after coming off the bench at the weekend.
Lionel Messi returned from a groin injury in Saturday’s 4-0 victory over Deportivo La Coruna and Jordi Alba and Sergi Roberto have also overcome injuries and are in contention.
Stats
– Barcelona have won all four of their previous encounters with Manchester City
– Barcelona have scored in each of their last 17 home Champions League games since September 2013.
– City have lost six of their last eight trips to Spain in European competition.
– Between them, Barcelona and Manchester City have scored 16 goals in their opening two group games so far. The only other side with more than six goals is Borussia Dortmund (eight).
Match Prediction and Odds
– 3-1 (NetBet odds 39/4)
– Lionel Messi to score first (NetBet odds 33/10)